NSD1 and neoplasm: This points to a functional role of NSD1 inactivation in the exclusion of immune cells from the tumor microenvironment and is consistent with our observations of a correlation between NSD1 expression and T cell infiltration (Fig. 3a and Supplementary Figure 7)To begin to understand how NSD1 inactivation may be affecting T cell infiltration, we compared the expression of an array of chemokine genes in the control cell lines to matched NSD1 knockdown cell lines.