PAK2 and skin disorder: Interestingly, Foxp3-Cre Pak2-deficient mice succumbed to death within 7–8 weeks after birth following the development of a more severe inflammatory disease compared to Cd4-Cre Pak2-deficient mice, evident by their runted size and the development of dermatitis, with multiple skin lesions apparent on the back, abdomen, tail and ears (Fig. 1a,b).