Our findings corroborate the results from previous Mendelian randomisation analyses showing no associations of genetically predicted BMI (based on 32 single nucleotide polymorphisms),41, 42, 43 diabetes,41 fasting glucose and insulin (based on 10 single nucleotide polymorphisms),41 cholesterol (with exclusion of genetic variants near APOE),41, 44, 45, 46 or triglycerides41, 44 with Alzheimer’s disease. Here, INS is linked to early-onset autosomal dominant Alzheimer disease.