And, sd-LDL is generated during the delipidation process by hepatic lipase (HL) from VLDL1 (TG-rich lipoprotein) to IDL and LDL particles and a number of clinical studies strongly suggest that a predominance of sd-LDL is associated with CVD risk, in hypertriglyceridemia [79] [80]. Here, LIPC is linked to hypertriglyceridemia.