Some of the detected PD-L1 mRNA expression changes were very high such as in lung squamous cell cancer (fold change = 4.9), bladder cancer (fold change = 4.1), head and neck cancer (fold change = 2.9), cervical cancer (fold change = 2.7) and cutaneous melanoma (fold change = 2.2). This evidence concerns the gene CD274 and urinary bladder carcinoma.