The tumor was 4 cm in size at that time, and no hormonal production had been detected (plasma renin activity (PRA), 0.5 ng/mL/h; plasma aldosterone concentration (PAC), 105 pg/mL; aldosterone/renin ratio (ARR), 210; the load test of furosemide in the standing position (PRA of 2.3 ng/mL/h, PAC of 236 pg/mL, ARR of 102.6); normal catecholamine and cortisol levels). This evidence concerns the gene REN and neoplasm.