The results showed that 2.0 mM VPA or 5 mg/ml Coptis Chinensis could reduce the expression of P-STAT3 (Fig. 8b), and Coptis Chinensis down-regulated HDAC3 and P-STAT3 in glioma cells, but it did not reduce the expression of STAT3 (Fig. 8c). Here, STAT3 is linked to central nervous system cancer.