There were only 3 outliers in these groups, trials showing a statistically significant benefit for the experimental group: the study by Mayer et al. [22] on the use of recombinant activated factor VII for ICH, the study of Rockswold et al. [23] on the use of hyperbaric oxygen for TBI and the controversial study of Cruz et al. [24] on the use of high dose mannitol for TBI with mydriasis. This evidence concerns the gene F7 and Mydriasis.