Our previous publications reported that the alleles for the serotonin transporter gene-linked promoter region (5-HTTLPR) s, and brain-derived neurotrophic factor (BDNF) met are associated with depression at the acute phase and its persistence at 1 year whereas proinflammatory cytokine polymorphisms including the tumor necrosis factor-α (TNF-α)-308 A allele and the interleukin (IL)-1β-511 T allele are associated with depression at the acute phase but not at 1 year in ACS [8–11]. The gene discussed is TNF; the disease is major depressive disorder.