TNF and depressive disorder: Despite the growing body of evidence showing the role of inflammation in the pathophysiology of suicide [1, 2] the weak positive associations, which were lost after adjustment, may be explained primarily by other factors, such as depression after ACS, as the association between the TNF-α and IL-1β polymorphisms and depression within 2 weeks after ACS was reported previously in our sample [31] as well as in general population [32].