ADIPOQ and neoplasm: Besides serving for lipid storage, adipose tissue is now recognized as an important endocrine organ [32, 33], secreting hormones such as adiponectin, leptin, interleukin (IL)-6, tumor necrosis factor α, IL-1β, and estrogen, most of which are linked to tumor proliferation, angiogenesis, invasion and metastasis [6–8].