The results indicated that CEP-1347 treatment reduced the expression levels of stem cell markers such as Sox2 and Bmi1 in all CSCs examined while inducing the expression of respective differentiation markers such as glial fibrillary acidic protein (GFAP) in glioma stem cells and E-cadherin in ovarian CSCs (Figure 1B). This evidence concerns the gene CDH1 and central nervous system cancer.