The results indicated that CEP-1347 treatment reduced the expression levels of stem cell markers such as Sox2 and Bmi1 in all CSCs examined while inducing the expression of respective differentiation markers such as glial fibrillary acidic protein (GFAP) in glioma stem cells and E-cadherin in ovarian CSCs (Figure 1B). The gene discussed is SOX2; the disease is glioma.