Given that the relationship between MIR217HG, Gab1 and lung cancer was undefined, the present study evaluated the relationship between MIR217HG-rs1347093, Gab1-rs1397529 polymorphisms and lung cancer susceptibility and investigated the interaction between MIR217HG-rs1347093, Gab1-rs1397529 polymorphisms and smoking status on the risk of lung cancer, which could provide a new strategy of lung cancer screening in Chinese population. The gene discussed is GAB1; the disease is lung cancer.