NBR1 is a multidomain protein which had several putative protein–protein interaction modules, such as an N-terminal phox/Bem1p (PB1) domain, a ZZ-type zinc finger (ZZ), a coiled-coiled (CC) region, autophagy receptor containing LC3-binding domain and C-terminal ubiquitin-associated (UBA) domain [20, 22, 25], however, the function of NBR1 in renal cancer remains unknown. Here, NBR1 is linked to renal carcinoma.