ccRCC is a malignant kidney cancer distinguished by early loss of Von Hippel-Lindau (VHL) tumor suppressor protein, leading to accumulation of the hypoxia-inducible transcription factor (HIF) [29–31], ccRCC is composed of lipid droplets in cell cytoplasm and HIF2α promoted lipid storage [32]. Here, EPAS1 is linked to nonpapillary renal cell carcinoma.