In the present study, we report the effects of exogenous COMP-Ang1 on vascular endothelial cells in adipose tissue, and its effects on adipocyte lipid diameter, macrophage infiltration, and serum free fatty acid (FFA), serum triglycerides, serum insulin, glucose levels, ICAM-1, VCAM-1 expression and macrophage recruitment in the kidney with a mouse model of diabetes induced by STZ. Here, ANGPT1 is linked to diabetes mellitus.