At present, many single nucleotide polymorphisms (SNPs) associated with lung cancer have been found by GWAS, Taqman probe (Taqman real time PCR) assays, DNA sequencing technology, such as CYFRA21-1 [5, 6], NSE [7], CA19-9 [8], KDM4A [9, 10], TP53 [11], KRT81 [12], etc. In epigenetic field, methylation, histone modification, RNA correlation silence, telomere are also relates with the development of lung cancer [13–16]. Here, ENO2 is linked to lung cancer.