CYP1A1-rs1048943 GG+AG genotype, GSTM1 deletion genotype, mEH-rs1051740 mutant genotype, XRCC1-rs1799782 TT+CT genotype, XRCC1- rs25489 GG genotype showed significant correlations with lung cancer risk increased. The gene discussed is XRCC1; the disease is lung cancer.