In Figure 5a, endogenous HIF1α showed no significant difference in different treatments, while in Figure 5b, the constitutive HIF1α (HIF1C) was not detectable in any of the treatments except the THP1/BA/CDM/HIF1C group, indicating a successful and sufficient HIF1C manipulation using lentivirus-carrying HIF1C infection. This evidence concerns the gene HIF1A and infection.