BIRC5 and ovarian carcinoma: To test whether an inhibition of BIRC5 expression with YM155 also induced cell apoptosis, both SKOV3 and OVCAR3 cells were treated with different doses from 50 to 200 nM; using Western blot, we detected apoptosis by examining cleaved PARP and caspase3 and found that inhibiting BIRC5 expression using YM155 induced cell apoptosis in both ovarian cancer cells (Figure 7D).