According to recent studies, XIST is up-regulated in several cancers, including hepatocellular carcinoma [12], gastric cancer [13], non-small cell lung cancer [14], glioma [15], and pancreatic cancer [16], the overexpression of XIST is highly associated with growth, invasion, and metastasis of these cancers. Here, XIST is linked to familial pancreatic carcinoma.