Thereafter, cells in which the high expression of Rab27a was silenced (H1650-Rab27a and SPC-A-1-Rab27a), their accordant control cells (H1650-scr and SPC-A-1-scr) and normal control cells were injected into the sides of the lower edge of the ribs subcutaneous, and tumor size was measured and registered every three days. This evidence concerns the gene RAB27A and neoplasm.