AFP and neoplasm: Although the present study did not show the clinical benefits of multikinase inhibitors due to the high frequencies of unfavourable pre-treatment factors, such as uncontrolled intrahepatic tumor, distant metastasis, and AFP of ≥ 400ng/Ml, in patients receiving sorafenib, aforementioned studies suggest that sequential or concurrent use of multikinase inhibitors with RT may prevent or delay intrahepatic or extrahepatic spread as well as enhance the tumor sensitivity to RT to metastatic LNs.