AFP and neoplasm: However, each risk factor has unequal impact on OS, i.e., hazard ratio for status of intrahepatic tumor, Child-Pugh classification, number of metastatic LNs, location of metastatic LNs, presence of distant metastasis, and serum level of AFP were 3.037, 2.590, 1.832, 1.889, 1.752, and 1.726, respectively (Table 2).