Hepatocyte growth factor (HGF) can induce endothelial cell proliferation and migration and improve endothelial function [31, 32], while endostatin, as an endogenous inhibitor of angiogenesis, directly affects endothelial cell function by inhibiting proliferation and migration, blocking endothelial cell motility, inducing apoptosis [1, 3, 33], and potently suppressing angiogenesis and tumor growth in animal models [2]. Here, COL18A1 is linked to neoplasm.