Our results showed that the combination of DM and E/Ea ratio > 9 was associated with an older age, higher prevalence of hypertension, coronary artery disease, and proteinuria, higher systolic blood pressure and BMI, higher levels of fasting glucose, triglycerides, calcium-phosphorous product, and uric acid, lower levels of albumin and hemoglobin, and lower eGFR, all of which could be associated with poor cardiac and renal outcomes. The gene discussed is ALB; the disease is Hypertension.