Results showed that MALAT1 knockdown significantly amplified DDP-induced repression of lung cancer cells viability, and reduced the lC50 values from 20.34 (A549/DDP) and 20.83 (H1299/DDP) to 14.19 (A549/DDP) and 13.21 (H1299/DDP) (Figure 2G and 2H). The gene discussed is MALAT1; the disease is lung cancer.