SOX9 and lung cancer: We already revealed that MALAT1 competes with SOX9 for miR-101, as well as miR-101 directly binds to SOX9 to inhibit SOX9 expression; this SOX9RE in the promoter of MALAT1 suggested that MALAT1, miR-101 and SOX9 forms a feedback loop to activate Wnt signaling pathway, finally acts on the chemo-resistance of lung cancer cell.