A possible reason for this lie in the knowledge that HDACi-induced apoptosis is attenuated by the B-cell lymphoma 2 (Bcl-2) family of anti-apoptotic proteins, including Bcl-xL and Mcl-1 [14], which have been shown to be up-regulated in EGFR-TKI resistant NSCLC cells [15, 16]. The gene discussed is BCL2; the disease is non-small cell lung carcinoma.