EGFR and non-small cell lung carcinoma: Since autophagy is closely related to apoptosis [31, 32] and might be involved in the resistance of NSCLC to EGFR-TKI [33], H1975 and PC-9GR cells were treated with the autophagy inhibitor spautin-1 (10 μM) to interfere with the combined effects of vorinostat and gefitinib.