Therefore, we investigated whether HA in pleural effusion could promote cell migration and invasion through the YAP1/TAZ-RHAMM axis in MPMs, and assessed the effects of statin compounds such as fluvastatin, which regulate RHAMM transcription by modulating YAP1/TAZ activity, on cell migration and invasion in MPMs. The gene discussed is HMMR; the disease is Pleural effusion.