Increased expression of AFAP1-AS1 was found in Barrett esophagus, esophageal adenocarcinoma, pancreatic ductal adenocarcinoma, nasopharyngeal carcinoma, hepatocellular carcinoma, cholangiocarcinoma, gallbladder cancer and gastric cancer [24-30]. Here, AFAP1 is linked to esophageal adenocarcinoma.