LEP and obesity due to melanocortin 4 receptor deficiency: When compared the accumulated genetic effects by above six leptin-associated loci (GPSleptin ) with all twelve selected loci (GPSall), GPSleptin showed equal or even more significant correlations with adiposity-traits than GPSall, thus, the six leptin-increasing SNPs may be used as a novel set of biomarkers to identify the risk of obesity.