MAP2K5 and obesity due to melanocortin 4 receptor deficiency: For other cardiometabolic traits (Table 5), the obesity predisposing locus, FTO-rs1558902 yielded significant association with systolic blood pressure (SBP) (P = 0.001), while the risk alleles of SNPs in/near GNPDA2, PCSK1 and MAP2K5 yielded nominal association with blood pressures (P < 0.05).