In summary, in our sample of Chinese children, we replicated eight adult East Asian obesity-related loci (in/near FTO, MC4R, GNPDA2, PCSK1, SEC16B, MAP2K5, ITIH4 and BDNF) in the same direction of effect as previous reports in adults. Here, PCSK1 is linked to obesity due to melanocortin 4 receptor deficiency.