MC4R and obesity due to melanocortin 4 receptor deficiency: When further adjusted for BMI (Table 6), the obesity predisposing loci, GNPDA2-rs16858082 (P = 0.016) and PCSK1-rs261967 (P = 0.026) were still nominally associated with total cholesterol (TC) levels, and MC4R-rs2331841 remained correlated with fasting glucose (FBG) levels (P = 0.012).