INS and obesity due to melanocortin 4 receptor deficiency: Obesity-related traits, blood pressures, triglyceride (TG), low density lipoprotein cholesterol (LDL-C), fasting insulin and homeostasis model assessment of insulin resistance (HOMA-IR) increased, while high density lipoprotein cholesterol (HDL-C) decreased, with increasing body mass index (BMI) (all P < 0.001).