In POLQ, a DNA polymerase involved in DNA repair with helicase activity, we found two variants predicted to be deleterious: p.P291L (C-terminal helicase domain) in two cases with CRC at 24 and 55 years and p.Y2420C (polymerase domain) in a case with CRC at 50 years. This evidence concerns the gene POLQ and colorectal carcinoma.