Next-generation sequencing (NGS) (whole genome or exome) has facilitated further discovery of cancer susceptibility genes including RECQL, FANCM, FANCC, XRCC2, POT1, and BAP1 for breast and melanoma [13], and POLE, POLD1, and NTHL1 for CRC [14, 15]. The gene discussed is NTHL1; the disease is colorectal carcinoma.