In MSH3 only p.A1064T was found in a female with MSI-High CRC at 62 years, other variants (p.D143N, p.L432W, p.I440M, p.V682L, and p.M892V) were in cases with MSS and MSI-Low CRC between 51 and 74 years. Here, MSH3 is linked to colorectal carcinoma.