Several genes had variants in both FCCTX-like and Lynch-like cases including all MMR genes (MLH1, MSH2, MSH6, and MSH3), HELQ, POLQ, LRIG1, PTCH1, LAMA2, and NOS1. Some MMR variants found in FCCTX-like MSS cases may still be pathogenic, since MMR mutations have been reported in MSS CRC patients, especially those with MSH6 mutations. This evidence concerns the gene MSH6 and colorectal carcinoma.