Based on a Taiwanese population, previous candidate-gene association studies showed a nominal association of MetS with several SNPs in the APOA5, BUD13, CETP, lipase A lysosomal acid type (LIPA), and five circadian clock genes including aryl hydrocarbon receptor nuclear translocator like (ARNTL), glycogen synthase kinase 3 beta (GSK3B), period circadian clock 3 (PER3), RAR related orphan receptor A (RORA), RAR related orphan receptor B (RORB); but none of these SNPs persisted significantly after performing Bonferroni correction [14, 15]. The gene discussed is RORA; the disease is metabolic syndrome.