Moreover, macrophage VEGFR1 expression, while dispensable for MAM recruitment, is determinant for the regulation of a set of prometastatic genes in MAMs, such as Csf1 in breast cancer lung metastases (Qian et al., 2015) or Mmp9 in B16 or LLC lung metastases (Hiratsuka et al., 2002, Kaplan et al., 2005). The gene discussed is CSF1; the disease is breast cancer.