TMEM168 and Anxiety: TMEM168 overexpression in the NAc increased anxiety in mice, such as entries (Fig 2A, p < 0.05, t = 2.844) and time (Fig 2B, p < 0.05, t = 2.2.253) on open arms in the elevated plus-maze) as well as time in the light box in light/dark box tasks (Fig 2C, p < 0.05, t = 2.964).