By contrast, the higher ORRs with sunitinib (11%), sorfenib (2-5.2%), pazopanib (30%), cediranib (34%) or bevacizumab + IFN-α (25.5-31%) obtained in previously untreated patients suggest that tumor regression might play a larger role in the improvement in PFS shown with angiogenesis inhibitors. The gene discussed is IFNA1; the disease is neoplasm.