Earlier trials using physiologic dose T showed limited clinical activity compared to the supraphysiologic levels achieved in the BAT studies, suggesting the anti-tumor efficacy of SPT may reflect the level of intratumoral androgens achieved on therapy, an effect that may be influenced by steroid transport and metabolizing enzymes such as SLCO1B3 and UGT2B17. Here, UGT2B17 is linked to neoplasm.