Notably, transcript expression of PDS5B ranges nearly an order of magnitude in CRPC tumors [112], while PLZF expression is reduced/lost in up to 86% of metastatic PCa specimens, with 5–7% of CRPC specimens harboring homozygous PLZF deletions [110,113], suggesting a possible role for androgen-induced expression of PDS5B or PLZF in promoting induction of a more differentiated cell state. This evidence concerns the gene ZBTB16 and posterior cortical atrophy.