Endogenous expression of SOX2 in prostate epithelial cells, human embryonic stem cells, and PCa cells is repressed by AR signaling (via an enhancer element within the SOX promoter), and loss of SOX2 expression has been shown to inhibit growth of the castration-resistant CWR-R1 PCa cell line [103]. This evidence concerns the gene SOX2 and posterior cortical atrophy.