The clinical relevance of continued AR signaling in promoting CRPC tumor growth is confirmed by the clinical responses to agents targeting residual androgen pathway activity including the striking clinical response observed with novel ligand synthesis inhibitors such as abiraterone (ABI), and potent AR inhibitors such as enzalutamide (ENZ) [44,45,46,47,48,49,50]. The gene discussed is AR; the disease is neoplasm.