Subsequently, immunohistochemistry (IHC) and RT-qPCR-based studies found USP22 abundance to be higher in cancerous than normal samples and associated with worse patients outcomes in multiple cancer types including colorectal, breast, esophageal, ovarian, pancreatic and stomach cancers [10,11,12,13,14,15,16,17,18,19]. Here, USP22 is linked to gastric cancer.