Subsequently, immunohistochemistry (IHC) and RT-qPCR-based studies found USP22 abundance to be higher in cancerous than normal samples and associated with worse patients outcomes in multiple cancer types including colorectal, breast, esophageal, ovarian, pancreatic and stomach cancers [10,11,12,13,14,15,16,17,18,19]. The gene discussed is USP22; the disease is gastric neoplasm.