USP22 and ovarian cancer: For example, at the mRNA level in ovarian cancer, USP22 is downregulated in 20% of cases and upregulated in 2.5% (Figure 3C); while collectively, at least one DUBm gene (USP22, ATXN7L3, ATXN7 or ENY2) is either downregulated in 47% of cases, or upregulated in 21% of cases (RNA-sequencing TCGA data) [37,51].