Since TDP-43 and tau pathology co-occur with α-syn pathology in PD, PDD, and DLB in humans [43, 69], and the presence of tau pathology influences α-syn pathology load in PDD [26, 70], we investigated whether PFFs injections could trigger tau and TDP-43 pathology after long post-injection times. The gene discussed is TARDBP; the disease is Parkinson disease.