Importantly, we found that cancer cells expressing the S-nitrosylation resistant isoform of PTEN (C83S) were significantly more sensitive to metabolic stress-inducing drugs 2-Deoxy-glucose (2-DG) and PDK inhibitor dichloroacetate (DCA),3 both of which result in the depletion of ATP and concomitant activation of AMPK. Here, PTEN is linked to cancer.