EPHA2 and colorectal carcinoma: A series of researches have demonstrated that hub genes in CRC, such as DHRS9 [4], GRIM-19 [5], EphA2 [6], and STYK1 [7], not only are involved in regulating a variety of cellular processes including cell proliferation, survival, differentiation, migration, and apoptosis but are also correlated with disease progression and prognosis of patients with CRC.