TIMP1 and colorectal carcinoma: More significantly, besides the aberrant expression of TIMP1 being confirmed by previous study, it is a marker of clinical significance in the diagnosis and prognosis of patients with colon carcinomas [46]; to the best of our knowledge, the current study is the first to report the prognostic value of CXCL3, ELF5, and PHLPP2 in CRC.