The results indicated that (1) the incidence of MYC and BCL2 gene rearrangements in HBV infection group was higher than that in HBV-free group; (2) the median OS and PFS of patients with HBV infection was worse than those with HBV-free; (3) multivariable analysis indicated that IPI, chemotherapy regimens, and MYC gene rearrangements were independent prognostic factors for DLBCL patients. This evidence concerns the gene MYC and diffuse large B-cell lymphoma.