KRT19 and hepatocellular carcinoma: On the other hand, the gross and histological evaluation of HCC specimens obtained by surgical resection has continuously allowed for the identification of histological subtypes including fibrolamellar (6, 7), lymphoepithelioma-like (8), and steatohepatitic HCC (9), as well as morphomolecular features such as the distinct patterns of vascular invasion (10) and the expression of stemness markers such as Keratin 19 (assessed by immunohistochemistry or by molecular pathology) (11, 12), well-established independent prognostic factors in HCC.