AQP6 and viral infectious disease: The aim of this study was to assess in greater detail consequences of virus-host cell interactions, focusing on whether and how the virus infection impacts wound-healing, cytoskeleton organization, IQGAP1 and AQP6 characteristics, and the cellular protein interactome associated specifically with the viral N. To achieve this, we used a Caco-2 epithelial cell migration assay, immunofluorescence imaging, immunoprecipitation, proteomics and bioinformatics.