FLT3 and acute myeloid leukemia: Lestaurtinib (CEP-701) is another first-generation multi-kinase inhibitor with activity against FLT3, Janus kinase 2, and tropomyosin receptor kinase A. One randomized trial tested lestaurtinib administration after induction chemotherapy in adult patients with AML in first relapse and demonstrated no survival benefit with lestaurtinib addition versus chemotherapy only (44).