However, in MARIANNE study (NCT01120184), 1095 recruited patients with HER2-positive advanced breast cancer were randomly assigned to three groups including trastuzumab + taxane (n = 365), T-DM1 + placebo (n = 367), and T-DM1 + pertuzumab (n = 363). The gene discussed is ERBB2; the disease is breast carcinoma.