As a result, more and more attention has been focused on the relationship between genetics and PD. LRRK2, one of the genes related to autosomal dominant form of PD, belongs to a member of the ROCO protein family [29] and has five major functional domains [30]: a leucine-rich repeat (LRR); a Roc domain (Ras in complex proteins); a COR domain (C-terminal of Roc); a TyrKc domain (tyrosine kinase catalytic), and WD40 domain. This evidence concerns the gene LRRK2 and Parkinson disease.