Taken together, SA3K protects against H2O2-induced oxidative stress in corneal epithelium by restoring the balance between ROS generation and degradation, as well as regulating the Keap1-Nrf2 signaling pathway, indicating that SA3K is a promising antioxidant factor that may serve as a potential therapeutic agent for the oxidative stress-related corneal diseases. The gene discussed is NFE2L2; the disease is corneal disorder.