Nrf2 is known as the molecular switch turning on/off the Nrf2 signaling (also known as Nrf2-Keap1 or Nrf2-Keap1-ARE signaling) and serves as a foremost component of ROS signaling pathway that can be activated by oxidative stress inducers, such as sulforaphane (SFN) [8] and hyperoside [9], and inhibited by oxidative stress factors such as homocysteine (Hcy) [10], O2 fluctuation [11], and hypoglycemia under hypoxia [12]. The gene discussed is KEAP1; the disease is Hypoglycemia.