In another study, observation in the early stage of diabetes and metabolic syndrome characterized by high level of VLDL, low HDL level, and constant level of LDL led to the conclusion that high LDL turnover is responsible for this cholesterol fraction, dependent on hyperinsulinemia, as in patients with full length diabetes type 2, wherein the insulin level is low and LDL had slower metabolism. The gene discussed is INS; the disease is diabetes mellitus.