Transcriptome analysis of mouse fibrotic dermis showed an increase in mRNA levels of regulatory genes, such as Col7a1, Ccn3/Nov, Biglycan, and Matrix Metalloproteinase 16 (Mmp16), a subset of which are also up-regulated in human skin fibrosis and tumor stroma (Hamburg-Shields et al., 2015). Here, CCN3 is linked to neoplasm.