Following intravenous inoculation of the melanoma cells, mice that received two doses (d0, d7) of CR3-deficient (CD11b−/−) NK cells by intravenous injection had significantly reduced metastatic tumor burden and less lung nodules, compared with the mice that received CR3-sufficient (WT) NK cells (Figures 3A–C), exhibiting a similar level of reduction in tumor nodules and burden as observed in CD11b−/− mice (Figures 2A–C). Here, CRIPTO3 is linked to melanoma.