Here, we present the recent developments at our understanding of the roles of some sepsis-related Siglecs family members (Siglec-1, Siglec-2, Siglec-5, Siglec-7, Siglec-9, Siglec-10, and Siglec-14) in immune regulation, and we also summarize current efforts to develop therapeutics targeting Siglecs for the treatment of sepsis (Table 1). Here, SIGLEC14 is linked to Sepsis.