ITGAE and melanoma: Recently, Zelenay et al. employed CRISPR-Cas9 gene editing technology to demonstrate that COX-derived PGE2 in a BRAFV600E melanoma cell line also suppresses costimulatory molecule expression on CD103+ and CD103−, CD11b+ tumor-infiltrating DC as well as IL-12p40 expression by the CD103+ DC subset (113).