Dacarbazine is the only FDA-approved chemotherapeutic agent for the treatment of melanoma, and though its use in isolation has not produced clinical benefits of major significance (63), it has been shown to promote the efficacy of a peptide-based vaccine for melanoma patients by enhancing repertoire diversity of Melan-A-specific CTL (64, 65), suggesting that the benefit of dacarbazine as part of combinatorial therapy may be derived from its induction of melanoma ICD. Here, MLANA is linked to melanoma.