Upregulation of β-catenin, which has been reported in DC that mature but that fail to fully activate and secrete proinflammatory cytokines (114), has been observed both in DC from lymph nodes draining B16-F10 tumors and in splenic DC cultured with B16-F10-conditioned media, and its induction in tumor-associated DC suppresses their ability to cross-prime CD8+ T cells (115). This evidence concerns the gene CD8A and neoplasm.