Another study has shown that melanoma-derived IL-10 and other unidentified factors contribute to an IL-12low, IL-10high phenotype in monocyte-derived DC capable of inducing CD4+ CD25+ FOXP3+ Treg development (125), and tumor-derived IL-6, VEGF, and TGFβ1 have all been implicated in the induction of IL-12low, IL-10high DC in the spontaneous Ret murine melanoma model (126). This evidence concerns the gene CD4 and melanoma.