While tumor microenvironment-specific differences in these ovarian cancer and melanoma models may explain differences in the impact of XBP1 on DC function, it is also possible that these discrepancies are due to differences in the particular DC under study, including the endogenous/exogenous nature of these cells and the extent of ER stress in the DC in which XBP1 is active. The gene discussed is XBP1; the disease is melanoma.