SOCS1 and neoplasm: Most recently, upregulation of the microRNA miR148-a in tumor-associated DC was shown to impair TLR-mediated maturation by suppressing expression of the DNA methyltransferase DNMT1, which in turn led to hypomethylation of the Socs1 gene and upregulation of the SOCS1 TLR signaling suppressor (117).