Differently from several models of systemic mycosis where NLRP3 inflammasome activation is associated with host protection and impairment of fungal growth (16–22), NLRP3 and caspase-1 deficient mice subcutaneously infected with F. pedrosoi developed to be self-healing in 30–40 days with a progressive fungal clearance. The gene discussed is CASP1; the disease is systemic mycosis.